Our mechanism of action explained
Once inside the cells, our siRNA molecules are recognised by the cellular machinery, which removes one of the strands (‘passenger strand’) of the siRNA construct and allows the other strand (‘guide strand’) to find its target mRNA and bind to it. This specific binding triggers the biological process of RNA interference (RNAi), by which said cellular machinery will degrade the target mRNA and prevent it from being translated into functional proteins.
We harness this natural pathway to develop new generation therapeutics by designing tailored siRNA sequences that are able to bind to mRNAs that code for disease-causing genes.
How do our siRNA based therapies work?