Our business model is designed to bring solutions to patients while generating shareholder value, by translating our proprietary technology into commercial drug products in a rapid and cost-effective way.



Investment case

Silence has been a pioneer in the RNAi field for over 18 years. Through the efforts of our skilled researchers and scientists, we have established an innovative  platform with broad intellectual property protection. Using our RNAi-directed platform technologies, we have generated siRNA product candidates both for our internal development pipeline as well as for out-licensed programs with third-party collaborators. We are currently focused on developing siRNA molecules for the potential treatment of cardiovascular disease, rare diseases such as iron overload disorders, and complement-mediated disorders.


Results, reports & presentations

Annual Report 2019

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Half Year Results 2020

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Full Year Results 2019

361KB Download

Half Year Results 2019

345KB Download

Full Year Results 2018

371KB Download

Half Year Results 2018

367KB Download

Annual Report 2019

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Annual Report 2018

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Annual Report 2017

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Annual Report 2016

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Annual Report 2015

978KB Download

Silence Therapeutics FY19 Results Announcement

175KB Download

Collaboration with AstraZeneca and R&D Update

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Silence Therapeutics HY20 Results Announcement

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955KB Download

Canaccord 40th Annual Growth Conference

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215KB Download

BTIG Virtual Biotechnology Conference

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215KB Download

William Blair Biotech Focus Conference

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Silence Therapeutics Fireside Chat at the RBC Capital Markets Global Healthcare Virtual Conference

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163KB Download

Corporate governance 

Our Corporate Governance framework is based on using the leadership provided by our Board to drive the effective execution of our strategy, ensuring that risk is appropriately mitigated and managed.


We have three Board Committees (Remuneration, Audit and Risk, and Nominations), focused on providing the required oversight to maintaining the highest Corporate Governance standards. Through these committees and regular interactions with the executive team, our Board applies internal financial controls and approves the Company’s policy and strategy.