Our business model is designed to bring solutions to patients while generating shareholder value, by translating our proprietary technology into commercial drug products in a rapid and cost-effective way.



Investment case

Silence is the only listed RNAi player in Europe and a pioneer in this technology. Through the efforts of our skilled scientists over the years we have established a robust platform that allows us to effectively trigger RNAi in specific cell types. Our inventions are protected by a broad intellectual property estate, which is a fundamental asset. Together with our progress, the fact that the field is generally maturing means that RNAi drugs are close to becoming a powerful genetic medicine modality at the disposal of doctors and patients.


“With the significant advancement of our liver delivery system, we will be able to deliver on the promise of RNAi being the next class of therapeutics”
Ali Mortazavi, Chief Executive Officer

Results, reports & presentations

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Full Year Results 2017

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Full Year Results 2017

298KB Download

Half Year Results 2017

154KB Download

Full Year Results 2016

898KB Download

Half Year Results 2016

614KB Download

Full Year Results 2015

1MB Download

Annual Report 2017

2MB Download

Annual Report 2016

1MB Download

Annual Report 2015

978KB Download

Annual Report 2014

9MB Download

Annual Report 2013

928KB Download

European Hematology Association 2018 - SLN124

976KB Download

BIO partnering - June 2018

1MB Download

Advanced GalNAc-siRNA Platform and Its Therapeutic Applications

1MB Download

9th CTIP - Use of Advanced siRNAs Targeted to Hepatocytes for the Development of Novel Drugs to Treat Liver-related Disorders

1MB Download

Oligo Oxford - Development of innovative hepatocyte-targeted siRNA conjugates for the treatment of liver-related disorders

1MB Download

Corporate governance 

Our Corporate Governance framework is based on using the leadership provided by our Board to drive the effective execution of our strategy, ensuring that risk is appropriately mitigated and managed.


We have three Board Committees (Remuneration, Audit and Risk, and Nominations), focused on providing the required oversight to maintaining the highest Corporate Governance standards. Through these committees and regular interactions with the executive team, our Board applies internal financial controls and approves the Company’s policy and strategy.