Pioneers in RNAi Therapeutics

With decades of scientific, molecular design and industry know-how, we create medicines that harness the body’s natural mechanism of RNA interference, or RNAi, to precisely target and silence disease-associated genes. Using our proprietary mRNAi GOLD™ (GalNAc Oligonucleotide Discovery) Platform, we are advancing a growing pipeline of wholly owned programs and partnership programs for diseases with significant unmet need. 


Our strategy is to develop RNAi-based therapeutics to tackle life-threatening diseases. We strive to do this in a risk-diversified manner to maximize our probability of success.

StrategyBullets_LeftHandColumn[1].png StrategyBullets_RightHandColumn.png (2)

Our People

Well equipped to drive execution

Mark Rother photo (trimmed).PNG

Management Team

Our management team is highly experienced in a variety of relevant sectors, from molecular biology and genetics to finance and investment banking. This combination of skillsets enables the team to effectively execute our business plan.

Strong leadership

Iain Ross 2.PNG

Board of Directors

Our Board provides oversight to ensure that the highest Corporate Governance standards are maintained, applies internal financial controls and approves the Company’s policy and strategy.

Access to distinguished experts and KOLs


Scientific Advisory Board

We aim to stay in the frontline of the fast-moving field of oligonucleotide therapeutics. Our Scientific Advisory Board (SAB) is a group of world-leading experts in drug discovery and clinical development with particular expertise in the rare disease space. The SAB challenges us to excel at siRNA molecular design, drug discovery, and development

Corporate responsibility

Silence strives to conduct its business in an ethical, responsible and transparent manner. We set high standards of conduct and behaviour and expect all our employees, officers and directors to adhere to those standards. Partners, employees, customers and suppliers can all expect the highest standards of professional conduct when dealing with our Company. The Board of Directors is responsible for setting and reviewing the Company’s values and standards.

Silence recognises and accepts its responsibility as an employer to maintain, as far as is reasonably practicable, the safety and health of its employees and of other persons who may be affected by its activities. Silence Therapeutics is an equal opportunities employer.



We’re a vibrant, growing, global company with a start-up mindset. One that begins with doing what we love and ends with fulfilling our vision. A vision to transform peoples’ lives around the world by silencing diseases through our precision engineered medicines and driving positive change for the communities around us. What we do is made special by how we do it, in accordance with our values.

If you are a passionate individual with a desire to make a difference, we would be delighted to hear from you.