Publications

MedNous commentary

Commentary on MedNous: has a la carte genetic medicine arrived?

CommentaryAliMortazaviSept2016


Targeted delivery of siRNA using transferrin-coupled lipoplexes specifically sensitizes CD71 high expressing malignant cells to antibody-mediated complement attack

Marc Cinci, Srinivas Mamidi, Wenham Li, Volker Fehring, Michael Kirschfink

Targeted Oncology, November 2014, DOI: 10.1007/s11523-014-0345-6


First-In-Human Phase-I study of the liposomal RNAi therapeutic Atu027 in patients with advanced solid tumours

Dirk Strumberg, Beate Schultheis, Ansgar Santel, Christiane Vank, Frank Gebhardt, Oliver Keil, Christian Lange, Klaus Giese, Jörg Kaufmann, Michael Khan, Joachim Drevs

Journal of Clinical Oncology, 17 November 2014, doi: 10.1200/JCO.2013.55.0376


Lung-targeted RNA-interference against Angiopoietin-2 ameliorates multi-organ dysfunction and death in sepsis

Stiehl, Thomas; Thamm, Kristina MS; Kaufmann, Jörg PhD; Schaeper, Ute PhD; Kirsch, Torsten PhD; Haller, Hermann MD; Santel, Ansgar PhD; Ghosh, Chandra C. PhD; Parikh, Samir M. MD; David, Sascha MD

Critical Care Medicine, October 2014 – Volume 42 – Issue 10 – p e654–e662


Delivery of Therapeutic siRNA to the Lung Endothelium via Novel Lipoplex Formulation DACC

Fehring V, Schaeper U, Ahrens K, Santel A, Keil O, Eisermann M, Giese K and Kaufmann J.

Molecular Therapy, April 2014, 22 4, 811–820


Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement-dependent anti-tumor activity of trastuzumab and pertuzumab

S. Mamidi, M. Cinci, M. Hasmann, V. Fehring, M. Kirschfink

Molecular Oncology, June 2013, 7, 3, 580-594.


Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation

Kristin Moepert, Katrin Loeffler, Nadine Roeder, Joerg Kaufmann, Ansgar Santel

European Journal of Cell Biology, September 2012, volume 91, issue 9, p.694-705


Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.

Strumberg D, Schultheis B, Traugott U, Vank C, Santel A, Keil O, Giese K, Kaufmann J, Drevs J.

International Journal of Clinical Pharmacology and Therapeutics, January 2012; 50(1):76-8


Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models

Santel A, Aleku M, Röder N, Möpert K, Durieux B, Janke O, Keil O, Endruschat J, Dames S, Lange C, Eisermann M, Löffler K, Fechtner M, Fisch G, Vank C, Schaeper U, Giese K, Kaufmann, J.

Clinical Cancer Research, November 2010, 16(22):5469-80


RNA interference for therapy in the vascular endothelium

Kaufmann J, Ahrens K, Santel A.

Microvascular Research, September 2010, 80(2):286-93